ࡱ> |~{Y R6Ebjbj888ZpeZpex x 8D\l~+& 2*******$-R0J*Q:::*H8+\\\:*\:*\\r&T'_[*&*N+0~+&0:0'0'$::\:::::**@:::~+::::0:::::::::x :  0uirS^NǏ z] z 0 zYef['Y~ zW,gOo`Course Information * zNx(Course Code)BI486*f[e(Teaching Hours)32*f[R(Credits)2* zTy(Course Name)uirS^NǏ z] zBioreaction and Bioprocess Engineering z'`((Course Type)_O/Compulsory Coursec[a(Audience),gyu/Undergraduatec(Language of Instruction)/English*_b|(School)u}Tyf[b/gf[b/Life Science and BiotechnologyHQO z(Prerequisite)uirSf[0_uirf[0~ހNRP[uirf[SS]StI{/Biochemistry, Microbiology, Cell and Molecular Biology, Chemical Engineering, etc.cYe^(Instructor)}vQfk/Fengwu Bai zQ@W(Course Webpage)*g^z/NA* z{N(Description)Yef[Q[;NSb NRI) ] zyf[W@x ;NcuirS^Ǐ zvir(Nϑa{ ~ހW{QNSuSO|vAmSL:N uirS^hV-NvAmR0mTS(ϑTpϑ O yr+R/f}Yl'`~ހW{QNSuǏ zv'l OI{] zyf[W@xwƋTStII) Ǐ zRRf[ ;NcvPSlSTWN_uir~ހW{QTSuvT{|uirS^SO| ͑p/fGWvS^T^GWvS^vǏ zRRf[yr_ :NuirS^Ǐ zOS`Y[W@xIII) uirS^hV] z ;NcuirS^hV!jW Sbt'`S^hVT^t`S^hVv!jWSel uirS^hV~gyr_I{0 z'`( z/f[uir] zNN,gyuv_O SOvQNNNf[u O0Yef[vhǏf[`N Of[uccT{|uirb/gNTuNmSvuirǏ z] zW@xwƋ yr+R/fuirS^hVv] zTd\OStI{0This course include three major sections: I) Engineering fundamentals, including mass and energy balance for bioreaction processes, rheological properties of cell culture and fermentation systems, mixing and transport performance of bioreactors, particularly oxygen mass transfer for aerobic cell culture and fermentation; II) Bioreaction kinetics for process optimization, including enzymatic catalysis and cell culture and fermentation under homogeneous and heterogeneous conditions; III) Bioreactor engineering, including models for ideal and non-ideal bioreactors and configurations of bioreactors for the production of various products. This course is compulsory for students majored in bioengineering and selective for students majored in other subjects. The objective is to train students with engineering principles for more efficient production of various bioproducts. zYef['Y~Course syllabus *f[`Nvh(Expections)(WuirSf[0_uirf[0W Of[S~ހTRP[uirf[I{W@xf[`NvW@x N ۏNekOf[uccuir] zNN_YvǏ z] zNNTuNvsQvNNwƋ0Based on their knowledge of science such as biochemistry, microbiology, genetics, and cell and molecular biology, students will be trained with  "$X\^fhjƿzpzkc\U hDVh%O hb4h:hb4h^<o( h^<o(hDVh:RHZo( h^PRHZhDVh0B*o(phhDVh:RHZh}3h}3RHZh^P hDVh:hDVh:o(hDVhGB*o(ph hDVh hDVh o( h h h h 5CJ aJ hHh^<5CJ \h^<5CJ \o(h^<5CJ \!$Z\hoccZcQc $Ifgd^P $Ifgd), $$Ifa$gdDV|kd$$Iflf;#&  t 0&644 lap ytDV $$Ifa$gdDV$a$gdT  $$Ifa$gd^< $$Ifa$gdDV 3** $Ifgd),kd$$Ifl/ֈ; +)# ?eq t0&644 layt^P      " B D n p r z |    H J N P R ^ b d l n p | ~ 쾷쨡衔씐씐hb4 hb4o(hDVh}o( hDVhilhDVhilo( h}mbh  h}mbh}mbh}mbh}mbo(hDVh B* phPhb4hb4o( hb4hb4hDVh o(h^P hDVh hDVh0B*o(ph8  " p ui $$Ifa$gdDVkdw$$Ifl40;# t0&644 laytL( $Ifgdb4p r | ~rri $Ifgd}mb $$Ifa$gdDVkd$$Ifl40;#  t0&644 laytL( ssg $$Ifa$gdDV $$Ifa$gdDVkd$$Ifl0;# t0&644 laytL(  J ` uii $$Ifa$gdDV $$Ifa$gdDV}kdL$$Ifl0;# t0&644 laytL(` b n uul $Ifgdb4 $$Ifa$gdDV}kd$$Ifl0;# t0&644 laytL( uul $Ifgdb4 $$Ifa$gdDV}kdr$$Ifl0;# t0&644 laytL( ( *    " 0 2 > @ B H N P R T \ ^ t v x $žžž|ungnu hThT h iohT hDVhThDVhTRHZo( h^PRHZhDVhTo(hDVhTB*o(ph hDVh%O hMh  hMhMhMhMo( hDVhCihhDVhCiho(hDVh}o(hDVh o(hb4 hb4o(hb4hb4o( hb4hb4 hDVh h^P&  B P uuuuuu $$Ifa$gdDV}kd$$Ifl0;# t0&644 laytL(P R x [O7dhN$G$IfWDXD`gd}3 $$Ifa$gdTkd$$Ifl\;# m t0&6 44 laytL( "$~raNN$IfXDYDgdT $$Ifa$gdDVkdG$$Ifl40;# t0&644 laytL($:,.24<>RTV::::::::::;l<<===ƶ}v hDVheeh(Yh9h9o(h,^ih,^io( hDVh9Uh9hz h o( h,^io( hto( h9o( hDVh h^P h^Po(hDVh o(hDVhtB*o(ph hDVhT h}mbhDVhT o( hDVhThT h hT)0~u $IfgdCihkd$$Ifl4a0;#  t0&644 laytL(02V::n<<q^QDQD & F$Ifgd9$If^gd9 & FN$IfWD8XDgd(Y$$IfUD]a$gd^P|kd$$Ifl-;#&  t 0&644 lap ytDVspecific knowledge of bioprocess engineering for biomanufacture.W{Qf[uSs0RgT㉳Quir] zNNvsQvR yr+R/fyb$R'``TR '`]\OvR0Through teaching and studies, students will be further trained with ability and capacity for critical thinking to detect and analyze problems associated with bioprocesses and production for solutions. zNec W{Qf[uVESR OvQ^uir] zُNetQMRlf[ySU\R`0The course will be taught in English to train students with inspiration and view to sense the frontier and dynamics of bioengineering as a new subject.*Yef[Q[0ۏ^[cSBl(Class Schedule& Requirements)Yef[Q[Contentsf[eHoursYef[e_Methodology\ONSBlAssignments[e_EvaluationPart I: Engineering fundamentalsAssignment IAssignment I1. Introduction1.0Teaching2. Mass and energy balance3.0Teaching3. Rheological properties and mixing 3.0Teaching4. Mass transfer3.0TeachingPart II: Bioreaction kineticsAssignment IIAssignment II5. Homogeneous Bioreaction Kinetics5.0Teaching6. Heterogeneous Bioreaction Kinetics5.0TeachingPart III: Bioreactor engineeringAssignment IIIAssignment III7. Ideal Bioreactors5.0Teaching8. No-ideal Flow and Real Bioreactors5.0TeachingSummarization2.0Teaching*8he_(Grading)g+gՋ70% z\ON30%70% from final examination and 30% from the 3 assignments, each with 10%*YePgbSDe(Textbooks & Other Materials)INHandout for teachingvQ[(More)e/NAYl(Notes)e/NA<== >,>L>V>h>n___SS $$Ifa$gd(Y$d4$Ifa$gdDVkd;$$Ifl)0;# t0&644 laytL(N$IfYD^gd(Y== > >>,>0>H>J>L>T>V>f>h>l>n>x>z>>>>>>>>>>>>>>>>$?&?*?B?D?\?`?b?d?f??????????????????@@@.@8@:@D@F@H@N@P@ۺۺۺۺۺۺh"h o( h"h h(Yh(Y hDVh(YhDVh(Yo(h(Yh h o( hDVh hDVh o(hDVh B*o(phFh>n>z>>>>>>>$$IfUDVD]^a$gd(Y>>>2#$d4$Ifa$gdDVkd$$Ifl4ֈ;}# << t0&644 laytL(>&?(?*?D?^?$$IfUDVD]^a$gd(Y $$Ifa$gd $Ifgd"^?`?b?2#$d4$Ifa$gdDVkd $$Ifl4ֈ;}# << t0&644 laytL(b??????$$IfUDVD]^a$gd(Y $$Ifa$gd $IfWDd`gd ???2#$d4$Ifa$gdDVkdd $$Ifl4ֈ;}# << t0&644 laytL(??????$$IfUDVD]^a$gd(Y $$Ifa$gd $IfWDd`gd ???2#$d4$Ifa$gdDVkd- $$Ifl4ֈ;}# << t0&644 laytL(?H@P@b@d@f@$$IfUDVD]^a$gd(Y $$Ifa$gd $IfWDd`gd P@`@h@j@l@n@p@r@|@@@@@@@@@@AA A$A(A*ArAxAzAAAAAAAABBDBHB`BdBfBBBBBBBBBBBBBBBB C&C(C8C@CBCDC\CxC~CChDVh0B*o(ph h h hL(h @o(hL(h @h(Yh"h o( h"h hDVh B*o(ph hDVh h Bf@h@j@2#$d4$Ifa$gdDVkd $$Ifl4ֈ;}# << t0&644 laytL(j@@@@@@$$IfUDVD]^a$gd(Y $$Ifa$gd $IfWDd`gd @@@2#$d4$Ifa$gdDVkd $$Ifl4ֈ;}# << t0&644 laytL(@@@@ A&A$$IfUDVD]^a$gd(Y $$Ifa$gd $Ifgd"&A(A*A2#$d4$Ifa$gdDVkd$$Ifl4ֈ;}# << t0&644 laytL(*ArAzAAAA$$IfUDVD]^a$gd(Y $$Ifa$gd $IfWDd`gdL(AAA2#$d4$Ifa$gdDVkdQ$$Ifl4ֈ;}# << t0&644 laytL(AAAAAA$$IfUDVD]^a$gd(Y $$Ifa$gd $IfWDd`gdL(ABB2#$d4$Ifa$gdDVkd$$Ifl4ֈ;}# << t0&644 laytL(BDBFBHBfBB$$IfUDVD]^a$gd(Y $$Ifa$gd $Ifgd"BBB2#$d4$Ifa$gdDVkd$$Ifl4ֈ;}# << t0&644 laytL(BBBBBB$$IfUDVD]^a$gd(Y $$Ifa$gd $IfWDd`gdL(BBB2#$d4$Ifa$gdDVkd$$Ifl4ֈ;}# << t0&644 laytL(B C(C:CC$$IfUDVD]^a$gd(Y $$Ifa$gd $IfWDd`gdL(>C@CBC2#$d4$Ifa$gdDVkdu$$Ifl4ֈ;}# << t0&644 laytL(BC^CfCxCzC|C$$IfUDVD]^a$gd(Y $$Ifa$gd $Ifgd |C~CCC2&& $$Ifa$gdDVkd>$$Ifl4ֈ;}# << t0&644 laytL(CCCCCCCCDD0DNDPDRDTDbDdDDDDDDDDDDDDDDDDDDDDDE E EEEEEEE E"E&E𿷰𙕎𙕎{{h9jh9U haTVh  hL(hT hL(hL(hL(o(h^PhhB*ph hhhh #o(hho(hDVhT B*o(ph hd[hd[hd[h(Y hT o(hd[hd[o( hDVhT hDVhT o(0CCPDRDdDDDDsgg $$Ifa$gdDVkd$$Iflr0;# t0&644 laytL( $$Ifa$gdDVDDDDDssj $IfgdL( $$Ifa$gdDVkd$$Ifl:0;# t0&644 laytL(DDD EEssj $IfgdL( $$Ifa$gdDVkd5$$Ifl 0;# t0&644 laytL(EEEE E$E&E*E,E0E2E4E6Etomomomommtgd~W WD`gdkd$$Ifl 0;# t0&644 laytL( &E(E,E.E4E6E haTVh h9jh9U6182P:p). A!"#$%S $$If!vh#v&:V lf  t 0&6,5&ap ytDV$$If!vh#v#v #v?#v#ve#vq:V l/ t0&6,55 5?55e5qayt^P$$If!vh#v#v :V l4 t0&6+,55 aytL($$If!vh#v#v :V l4 t0&6+,55 aytL($$If!vh#v#v :V l t0&6,55 aytL($$If!vh#v#v :V l t0&6,55 aytL($$If!vh#v#v :V l t0&6,55 aytL($$If!vh#v#v :V l t0&6,55 aytL($$If!vh#v#v :V l t0&6,55 aytL($$If!vh#v#v #v#vm :V l t0&6 ,55 55m aytL($$If!vh#v#v :V l4 t0&6+,55 aytL($$If!vh#v#v :V l4a t0&6+,55 / aytL($$If!vh#v&:V l-  t 0&6,5&ap ytDV$$If!vh#v#v :V l) t0&6,55 aytL($$If!vh#v#v#v#v #v<:V l4 t0&6+,5555 5<aytL($$If!vh#v#v#v#v #v<:V l4 t0&6+,5555 5<aytL($$If!vh#v#v#v#v #v<:V l4 t0&6+,5555 5<aytL($$If!vh#v#v#v#v #v<:V l4 t0&6+,5555 5<aytL($$If!vh#v#v#v#v #v<:V l4 t0&6+,5555 5<aytL($$If!vh#v#v#v#v #v<:V l4 t0&6+,5555 5<aytL($$If!vh#v#v#v#v #v<:V l4 t0&6+,5555 5<aytL($$If!vh#v#v#v#v #v<:V l4 t0&6+,5555 5<aytL($$If!vh#v#v#v#v #v<:V l4 t0&6+,5555 5<aytL($$If!vh#v#v#v#v #v<:V l4 t0&6+,5555 5<aytL($$If!vh#v#v#v#v #v<:V l4 t0&6+,5555 5<aytL($$If!vh#v#v#v#v #v<:V l4 t0&6+,5555 5<aytL($$If!vh#v#v#v#v #v<:V l4 t0&6+,5555 5<aytL($$If!vh#v#v :V lr t0&6,55 aytL($$If!vh#v#v :V l: t0&6,55 aytL($$If!vh#v#v :V l  t0&6,55 aytL($$If!vh#v#v :V l  t0&6,55 aytL(w666666666vvvvvvvvv666666>6666666666666666666666666666666666666666666666666hH6666666666666666666666666666666666666666666666666666666666666666662 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@6666 OJPJQJ_HmH nHsH tHJ`J )cke $1$a$ CJKH_HaJmH nHsH tH$A $ ؞k=W[SOBi@B 0nfh*B*S*Y(phDbD ~W0u w9r G$Pa$CJaJ*/q* ~W0u w W[&{CJaJ: : ~W0u9r G$a$CJaJ*/* ~W0u W[&{CJaJPK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭Vwmc>+4ݭ]`SIC^! \LaW3Zshz~UR;\tꍊdf$YtGQ{Bd(Kp_c?D21@>GR.e1a$n%NݜIxsrRicDKP jdC %R)c55vvZU}ʽ3D;>L7cTEB‹_?~2:Ȅ#kȍO& NkzN8'0hts@.n6\Vru6k C9W-ù_ A`?^R|{֯A)oViנt] f9dQ)/Pyt),b-FO@)$zh O_,"%JJ2'Pt!h3xbRv;7 ^xO^>K6Veda/޿o_~N&ZS=īzOthrtb'$»Ͻ,:&'rS,Jš(# }o(rzضczbG|%C(njN+Usf{r2q:sGj )T#l|@Q"'Xz;ر zL 6އ!4ɄXTv[9~uzl$D'ZfV.SGHF.5ΰ.k8.t1]6Kry3vڏPta$LBytC3%{`o ÚQoVۘY;^9®T展b8ZX}1Eh[Z6/H߉ bW`Av f7Oa/>ijFI>͇'6c# B8r_#j}!g5w=Ede 2k EL\D,"jSnnoY=OL75@[Ok}xw|;[.%[>vSg|FfV ed7a]4-׍̾v㺑nd 5#=ч>39t, }#lJN{ pGU` Hx?#á,Dz!%pfc6K:UuVVd1^ q8),rBn(ː0&I$Ae$} Fs+{+,-~@- |[z!8|z]̷}ƴ"Mn+{VBOs:XI{νXج*Έjj<UkEJ]F((f2O:tSn)[30IVOFi^5R{匤YL+b 2e˫yĐ 亭>!`~{`P+&)ƻiXlԮEks:RԖW6;yc]J] AC4=I6`<րOފQ%Z/UZԃJvn֫ðZjϠ(/:;Ɣe/˚\u5{Gڨ]ov;*^7zA=3~Jj_ E.5Z4a}14}dj^ PK!ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э56?$Q,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 0_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!: theme/theme/theme1.xmlPK-!ѐ' theme/theme/_rels/themeManager.xml.relsPK]   $=P@C&E6E $.@E p ` P 0<h>>>^?b?????f@j@@@&A*AAAABBBBB>CBC|CCDDE6E #%&'()*+,-/0123456789:;<=>?ABCDT # @H 0(  0(  B S  ?_GoBackmm/3rv%'@H} !$*.<@KM *,-2@BF8 _  ' + 5 7 > B O T a e QUvw<, + , 7 8 B C T U e f 4 6 V X  i <<Z<rI,\#|60Bj&YA\^`\o( H\^H`\hH) \^`\hH. \^`\hH. 4\^4`\hH)  \^ `\hH. | \^| `\hH.  \^ `\hH) \^`\hH.H^H`o(.(\^(`\)\^`\.p\^p`\. \^ `\) \^ `\.\\^\`\.\^`\)\^`\.h^h`o(H\^H`\)\^`\.\^`\.4\^4`\) \^ `\.| \^| `\. \^ `\)\^`\. \^`\hH. H\^H`\hH) \^`\hH. \^`\hH. 4\^4`\hH)  \^ `\hH. | \^| `\hH.  \^ `\hH) \^`\hH.I,\#|6Z<0Bj^        !:        ^                  mDVmT\1 T  kO a[ K "5XO:),su+ROz hls)GI } 4z" #l&Q&V&6'+(:F(L(}*Ie*y*7e+60724b4g67p7H9FR9W9"D<=e>hDFWDGzH!ISAMbM;(N1PPQ RaTVWgtW~WR[I_Ya}mbdie`;fCih,^ijE6mIoIo ioVTpuptJx-_yz6 |@}wK~X:\St8^<Tr}NO`%>X!D(:=}3z seeduL2L`VQe7}~ild[_Tc(9tCp+@^Pk80 (X9Zh2s0u;#3MzDM<:PRXW)]{g%&d !9K]P%OS% p@)0b lF(Y}h @M@L @:Unknown G.[x Times New Roman5Symbol3. .Cx Arial7.*{$ Calibri;([SOSimSun7: Symeteo9,|8I{~ Light?|8I{~DengXianA$BCambria Math qhjG"jjG  !?!%),.:;>?]}    & 0 2 3 : !6"000 0 00000006:>@DZ\^ =@\]^$([{  0 0 000000Y[];[r;qHP  $P2!xx  xiqiang yangDELL    Oh+'0p   , 8DPX`hxiqiang yangNormalDELL14Microsoft Office Word@CG@SFZ@Z@&[  ՜.+,0 hp|    Title  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFHIJKLMNOPQSTUVWXYZ[\]^_`abcdefghijlmnopqrtuvwxyz}Root Entry F e[Data Gc1TableR0WordDocument8SummaryInformation(kDocumentSummaryInformation8sCompObjn  FMicrosoft Word 97-2003 ĵ MSWordDocWord.Document.89q